Since the follicular walls in the pilo-sebaceous unit is untouched before puberty, it has been postulated that if colonization of Proprionibacterium acnes happens in sufficient quantities they produce antigenic molecules that promote the initiation of inflammation. Proprionibacterium acnes is able to synthesize proteinases, lipase, and hyaluronate lyase all of which may serve as the accelerators or promoters of the inflammatory infiltrate which is made of neutrophils and lymphocytes.

Hormonal Cause of Acne

The crucial player in the cause of acne in puberty is hormones. At this stage androgens interact with receptors on the sebaceous glands and cause activation of the sebaceous gland to hypertrophy and so induce more sebaceous production of lipids and free fatty acids which distend the follicular conduct. More specifically, there is evidence for increased peripheral metabolic conversion of the androgen testosterone to dihydrotestosterone at the level of the skin in persons having acne.

How Acne Forms

The first lesion in this condition called acne vulgaris is the comedo. When in contact with oxygen the comedo becomes dark and creates what you know as a blackhead. The comedo is made by retention of layers of dead skin known as keratin in the walls of the follicles. In addition to hyperkeratosis (which is thickening or retained layers of keratin), there is an aggregation of sebum. The combination of the keratin and the sebum produces a plugging of the opening of the follicular conduct, and papules are formed by inflammation around the comedones. Depending on the degree of inflammation, cars, nodules, pustules, granulomatous reactions, cysts, and keloids may develop.

Development of Acne

Inflammatory Reaction

Airborne contamination and other toxic materials further aggravate the inflammatory response. As bacteria begin to proliferate inside the blocked pore your defensive system reacts by releasing granulocytes and macrophages, which are types of white blood cells that destroy the bacteria. The inflammation process is needed to eliminate the continuing consequences of excess bacteria and signal the body to repair the harm to tissues. Often times the defensive response system can't stop the reproduction of acne bacteria due to lack of leukocytes or an impaired system.

Activity of the Sebaceous Gland

When a comedo is clogging the outlet of the sebum ducts, the sebaceous glands continue to produce sebum, which accumulates in the sebum conduct increasing the comedo in size. The expansion in size produces pressure and leads to a further intense inflammation response in the surrounding skin and produces redness, discomfort, swelling, and a mass (pimple, redhead, acne papule).

Growth of Acne Bacteria

The above conditions encourage the growth of bacteria and result in infection inside the canal, the sebaceous gland, and surrounding tissue. The commencement of the infection produces further inflammatory changes, therefore starting a cycle of accentuated obstruction of the outflow of sebum which produces even more pressure, inflammation, and progressing infection making cysts and pustules to occur. The consequence on skin tissues caused by such infections is very damaging and the healing process usually results in a scar.

Treatments For Acne

To find a good pimple remedy, you must remember that everyone has different needs. Try various acne products, beginning with the milder one, until you find what works for you. A good skin treatment can be the end of your acne.

Scars, imperfections and marks produced by various acne conditions can now be easily eliminated thanks to a biological skin care product elaborated with a hypoallergenic, non-irritant special component for the rejuvenation of your skin.